Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378015 | 0.90 | HRH3 (0.45) | HRH3HRH1CCR3KCNH2CXCR4 | |
| SCHEMBL3375950 | 0.88 | CXCR4 (0.44) | HRH3KCNH2CXCR4ROCK1ROCK2 | |
| SCHEMBL3377859 | 0.86 | HRH3 (0.44) | HRH3HRH1CCR3CXCR4RORC | |
| SCHEMBL3376046 | 0.85 | HRH3 (0.44) | HRH3CXCR4SOS1OPRM1OPRD1 | |
| SCHEMBL3381250 | 0.84 | CXCR4 (0.35) | HRH3CXCR4KEAP1NFE2L2CCR5 | |
| SCHEMBL3376020 | 0.84 | CACNA1B (0.42) | HRH3HRH1CCR3KCNH2RORC | |
| SCHEMBL3380045 | 0.84 | HRH3 (0.44) | HRH3HRH1CCR3KCNH2CXCR4 | |
| SCHEMBL3376233 | 0.83 | HRH3 (0.42) | HRH3HRH1CCR3KCNH2CXCR4 | |
| SCHEMBL3377343 | 0.83 | SOS1 (0.44) | HRH3CXCR4SOS1EPHX2ALDH1A1 | |
| SCHEMBL3377335 | 0.83 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |