Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 0.89 |
| ▸ | EGFR | P00533 | 3/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375267 | 1.00 | ERBB2 (0.89) | ERBB2EGFRKCNH2 | |
| SCHEMBL3375659 | 1.00 | ERBB2 (0.89) | ERBB2EGFRKCNH2 | |
| SCHEMBL5152803 | 0.94 | ERBB2 (1.00) | ERBB2EGFRKCNH2 | |
| SCHEMBL3376483 | 0.94 | ERBB2 (1.00) | ERBB2EGFRKCNH2 | |
| SCHEMBL3375767 | 0.94 | ERBB2 (1.00) | ERBB2EGFRKCNH2 | |
| SCHEMBL3375094 | 0.91 | ERBB2 (0.89) | ERBB2EGFRKCNH2 | |
| SCHEMBL5062788 | 0.91 | ERBB2 (0.89) | ERBB2EGFRKCNH2 | |
| SCHEMBL3380349 | 0.91 | ERBB2 (0.89) | ERBB2EGFRKCNH2 | |
| SCHEMBL3379109 | 0.89 | ERBB2 (0.86) | ERBB2EGFRKCNH2 | |
| SCHEMBL3375062 | 0.89 | ERBB2 (0.86) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928861-B1 | 4- (IH-INDAZOL-5-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2010-11-17 | — | — | EP | disclosed |
| EP-1928861-A1 | 4- (IH-INDAZOL-S-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007034144-A1 | 4- (IH-INDAZOL-S-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |