Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 3/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377338 | 0.90 | HRH3 (0.40) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3378522 | 0.90 | HRH3 (0.40) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3378100 | 0.88 | HRH3 (0.40) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3376099 | 0.87 | HRH3 (0.40) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3381202 | 0.86 | HRH3 (0.39) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3380335 | 0.85 | HRH3 (0.39) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3380203 | 0.85 | HRH3 (0.48) | HRH3KMT2AMEN1POLBMCHR1 | |
| SCHEMBL3379864 | 0.85 | HRH3 (0.39) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3377452 | 0.85 | HRH3 (0.40) | HRH3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3377403 | 0.84 | KMT2A (0.44) | HRH3KMT2AMEN1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |