Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 16/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BCL6 | P41182 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382687 | 0.92 | CNR2 (0.63) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3380830 | 0.92 | CNR2 (0.61) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3382325 | 0.91 | CNR2 (0.62) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3380806 | 0.89 | CNR2 (0.62) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3379885 | 0.88 | CNR2 (0.58) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3382335 | 0.88 | CNR2 (0.72) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3382843 | 0.87 | CNR2 (0.58) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3383614 | 0.86 | CNR2 (0.57) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3383239 | 0.86 | CNR2 (0.74) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3380884 | 0.86 | CNR2 (0.58) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878725-B1 | Pyrimidine derivatives and their use as CB2 modulators | GLAXO GROUP LTD (GB) | 2010-11-24 | — | — | EP | claimed |