SCHEMBL3379770

SCHEMBL3379770

CCc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1

nearest known ligand 0.77

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 14/20 0.77
HTR2C P28335 3/20 0.77
HTR2B P41595 3/20 0.77
HTR2A P28223 1/20 0.77
HTR6 P50406 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2284875 0.87 SLC6A4 (1.00) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL2284067 0.82 SLC6A4 (1.00) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL3380610 0.78 SLC6A4 (0.62) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL2288650 0.77 SLC6A4 (0.65) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL2280406 0.76 SLC6A4 (0.66) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL2286134 0.75 SLC6A4 (1.00) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL2284441 0.74 SLC6A4 (0.58) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL2286040 0.74 SLC6A4 (1.00) SLC6A4HTR2CHTR2BHTR6
Hydrochloric Acid SCHEMBL2280350 0.74 SLC6A4 (0.57) SLC6A4HTR2CHTR2BHTR2AHTR6
SCHEMBL2284230 0.72 SLC6A4 (1.00) SLC6A4HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010059393-A1 SEROTONIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2010-05-27 WO claimed