Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.47 |
| ▸ | HTR2C | P28335 | 14/20 | 0.47 |
| ▸ | HTR2B | P41595 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2341735 | 0.89 | HTR2C (0.60) | HTR2AHTR2CHTR2BKMT2AHSD17B10 | |
| SCHEMBL2338980 | 0.85 | HTR2C (0.58) | HTR2AHTR2CHTR2BHSD17B10KDM4E | |
| SCHEMBL2343409 | 0.83 | HTR2C (0.57) | HTR2AHTR2CHTR2BKMT2AKDM4E | |
| SCHEMBL2339041 | 0.78 | HTR2C (0.46) | HTR2AHTR2CHTR2BKMT2AKDM4E | |
| SCHEMBL2336470 | 0.78 | HTR2C (0.43) | HTR2AHTR2CHTR2BMAPTKMT2A | |
| SCHEMBL12449410 | 0.73 | HTR2C (0.41) | HTR2AHTR2CHTR2BKDM4EALDH1A1 | |
| SCHEMBL12448467 | 0.73 | HTR2C (0.40) | HTR2AHTR2CHTR2BMAPTKDM4E | |
| SCHEMBL2339714 | 0.72 | HTR2C (0.58) | HTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL2340772 | 0.71 | HTR2C (0.60) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL12449411 | 0.71 | HTR2C (0.38) | HTR2AHTR2CHTR2BKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053825-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-14 | — | — | WO | claimed |