Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | CDH1 | P12830 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | LSS | P48449 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378914 | 1.00 | PPARA (0.45) | PPARACDH1CTNNB1TCF7L2ESR1 | |
| SCHEMBL3378769 | 0.93 | PPARA (0.43) | PPARAESR1ESR2LSSTHRB | |
| SCHEMBL3378899 | 0.93 | PPARA (0.43) | PPARAESR1ESR2LSSTHRB | |
| SCHEMBL3376832 | 0.89 | PPARA (0.53) | PPARALSSPPARD | |
| SCHEMBL3376890 | 0.89 | PPARA (0.52) | PPARALSSPPARD | |
| SCHEMBL3376886 | 0.89 | PPARA (0.53) | PPARALSSPPARD | |
| SCHEMBL3377321 | 0.89 | PPARA (0.52) | PPARALSSPPARD | |
| SCHEMBL4389863 | 0.77 | ESR1 (0.35) | CDH1CTNNB1TCF7L2ESR1ESR2 | |
| SCHEMBL3376909 | 0.73 | PPARD (0.53) | PPARAPPARD | |
| SCHEMBL3376978 | 0.73 | PPARD (0.53) | PPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796665-B1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK SHARP & DOHME (US) | 2010-11-17 | — | — | EP | disclosed |