Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 19/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383266 | 0.95 | CNR2 (0.73) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3382343 | 0.95 | CNR2 (0.60) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3380784 | 0.91 | CNR2 (0.56) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3379058 | 0.90 | CNR2 (0.55) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3382869 | 0.88 | CNR2 (0.61) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3377741 | 0.87 | CNR2 (0.73) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3378862 | 0.87 | CNR2 (0.60) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3381119 | 0.86 | CNR2 (0.59) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL13070070 | 0.85 | CNR2 (0.90) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3379074 | 0.84 | CNR2 (0.57) | CNR2CYP1A2CYP2C19CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878725-B1 | Pyrimidine derivatives and their use as CB2 modulators | GLAXO GROUP LTD (GB) | 2010-11-24 | — | — | EP | claimed |