Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 16/20 | 0.72 |
| ▸ | KDR | P35968 | 16/20 | 0.72 |
| ▸ | FLT1 | P17948 | 7/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383481 | 1.00 | FGFR1 (0.72) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3383776 | 0.93 | FGFR1 (0.62) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL14796668 | 0.93 | FGFR1 (0.62) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3383527 | 0.83 | FGFR1 (0.83) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3381059 | 0.83 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3384520 | 0.82 | FGFR1 (0.62) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3382209 | 0.82 | FGFR1 (0.62) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3381524 | 0.81 | FGFR1 (0.71) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3383522 | 0.81 | FGFR1 (0.51) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL14796636 | 0.80 | FGFR1 (0.73) | FGFR1PDGFRBKDRFLT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497287-B1 | Quinoline derivatives in combination with 5-FU or CPT-11 for use in the treatment of cancer | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-11-24 | — | — | EP | disclosed |