Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.67 |
| ▸ | PDE1A | P54750 | 2/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3012186 | 0.88 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| Tunodafil SCHEMBL3018511 | 0.87 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CADORA3 | |
| Tunodafil SCHEMBL3023706 | 0.86 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CADORA3 | |
| Tunodafil SCHEMBL3011726 | 0.86 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CADORA3 | |
| SCHEMBL3012495 | 0.85 | PDE5A (0.74) | PDE5APDE1APDE1BPDE1CADORA2A | |
| SCHEMBL3026814 | 0.85 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3031282 | 0.84 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CADORA2A | |
| SCHEMBL3023423 | 0.84 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3023508 | 0.83 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3022651 | 0.82 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1634883-B1 | 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE[2,3-D] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF | YANGTZE RIVER PHARMACEUTICAL G (CN) | 2010-12-15 | — | — | EP | claimed |