Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.67 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 8/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369499 | 0.90 | TNF (0.66) | TNFNOD1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL2368912 | 0.89 | TNF (0.67) | TNFNOD1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL2369262 | 0.89 | TNF (0.64) | TNFNOD1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL2368060 | 0.88 | TNF (0.66) | TNFNOD1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL2368545 | 0.87 | TNF (0.70) | TNFNOD1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL2368488 | 0.85 | TNF (0.59) | TNFNOD1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL2368584 | 0.85 | TNF (0.67) | TNFNOD1MAPK1SMN1; SMN2PIP4K2C | |
| SCHEMBL2368361 | 0.85 | TNF (0.56) | TNFNOD1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL3382742 | 0.84 | TNF (0.70) | TNFNOD1MAPK1SMN1; SMN2PIP4K2C | |
| SCHEMBL2368495 | 0.84 | ESR1 (0.73) | TNFNOD1MAPK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| CN-1823071-A | Thienopyrimidine derivatives as potassium channel inhibitors | XENTION DISCOVERY LTD (GB) | 2006-08-23 | — | — | CN | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |