Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRB2 | P62993 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 8/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383256 | 0.89 | GRB2 (0.44) | GRB2SLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL3385767 | 0.89 | SLC7A5 (0.47) | GRB2SLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL3386209 | 0.88 | GRB2 (0.43) | GRB2SLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL3385922 | 0.80 | PTPN1 (0.60) | GRB2SLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL3385768 | 0.79 | SLC7A5 (0.48) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3384873 | 0.79 | GRB2 (0.45) | GRB2SLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL1983960 | 0.78 | PTPN1 (0.44) | GRB2SLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL3385897 | 0.77 | GRB2 (0.44) | GRB2SLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL3383317 | 0.77 | SLC7A5 (0.46) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL3382296 | 0.77 | GRB2 (0.43) | GRB2SLC7A5PTGS1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445706-B2 | Unnatural amino acids capable of covalently modifying protein phosphatases and their use as general and specific inhibitors and probes | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2013-05-21 | — | — | US | claimed |
| US-20100061936-A1 | UNNATURAL AMINO ACIDS CAPABLE OF COVALENTLY MODIFYING PROTEIN PHOSPHATASES AND THEIR USE AS GENERAL AND SPECIFIC INHIBITORS AND PROBES | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY | 2010-03-11 | — | — | US | claimed |
| US-20120245029-A1 | NOVEL PHOSPH(ON)ATE- AND SULF(ON)ATE-BASED PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245029-A1 | NOVEL PHOSPH(ON)ATE- AND SULF(ON)ATE-BASED PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS | TYMP, PNP, MTAP | GRB2 2001/4885SLC7A5 1095/4885PTGS1 3931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.