Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4316805 | 0.78 | GAA (0.46) | GAANPSR1NPC1RAB9APOLB | |
| SCHEMBL3386016 | 0.71 | CACNB4 (0.46) | GAAPOLBALDH1A1KDM4ECYP1A2 | |
| SCHEMBL25802168 | 0.71 | GAA (0.57) | GAANPSR1NPC1RAB9APOLB | |
| SCHEMBL3386168 | 0.70 | POLB (0.48) | POLBMAPTALDH1A1KDM4EKDR | |
| SCHEMBL3835741 | 0.69 | GAA (1.00) | GAANPSR1NPC1RAB9AMAPT | |
| SCHEMBL4182812 | 0.68 | POLB (0.48) | POLBMAPTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4178385 | 0.68 | F2R (0.50) | GAAPOLBMAPTALDH1A1KDM4E | |
| SCHEMBL23240068 | 0.68 | GAA (0.52) | GAANPSR1NPC1RAB9APOLB | |
| SCHEMBL29716288 | 0.68 | GAA (0.52) | GAANPSR1NPC1RAB9APOLB | |
| SCHEMBL25802440 | 0.67 | GAA (0.57) | GAANPSR1MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806141-B1 | PAR-2 ANTAGONISTS | KOWA CO (JP) | 2010-12-01 | — | — | EP | disclosed |
| EP-1806141-A1 | PAR-2 ANTAGONISTS | Kowa Company, Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |