Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 9/20 | 0.56 |
| ▸ | RAF1 | P04049 | 3/20 | 0.56 |
| ▸ | BRAF | P15056 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | BCR | P11274 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | LDLR | P01130 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387073 | 0.93 | RAF1 (0.56) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL3386597 | 0.90 | BRAF (0.53) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL3387255 | 0.85 | CSF1R (0.54) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL3387502 | 0.81 | RAF1 (0.55) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL3383253 | 0.79 | NTRK1 (0.59) | CSF1RMAPTKDM4EPOLBKIT | |
| SCHEMBL12292400 | 0.77 | NR2E1 (0.63) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL15381989 | 0.77 | CSF1R (0.71) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL3383196 | 0.76 | RAF1 (0.54) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL1420281 | 0.75 | NR2E1 (0.74) | NR2E1RAF1BRAFABL1BCR | |
| SCHEMBL3386584 | 0.75 | KDR (0.63) | CSF1RKITEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |