Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.58 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | FBP1 | P09467 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | STAT3 | P40763 | 2/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | HTR1E | P28566 | 1/20 | 0.54 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.54 |
| ▸ | STAT1 | P42224 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386872 | 0.92 | KDM4E (0.56) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL3384246 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL3383018 | 0.82 | NTRK1 (0.55) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL6100814 | 0.74 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL3653095 | 0.74 | EPHX2 (0.77) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL6101644 | 0.73 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL4491590 | 0.73 | HDAC1 (0.61) | KDRHDAC1HDAC2HDAC8 | |
| SCHEMBL2866772 | 0.72 | EPHX2 (0.52) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL6101654 | 0.72 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNANPSR1HSD17B10MAPT | |
| SCHEMBL6100605 | 0.71 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNANPSR1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |