Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6360281 | 0.92 | TNF (0.49) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL3387496 | 0.83 | CSNK1D (0.51) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL2369183 | 0.80 | TNF (0.56) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL12817292 | 0.78 | TNF (0.52) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL15893245 | 0.78 | TNF (0.52) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL12817304 | 0.78 | TNF (0.52) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL12818588 | 0.78 | TNF (0.52) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL3387615 | 0.78 | TNF (0.59) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL3386735 | 0.76 | TNF (0.59) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL2368519 | 0.76 | TNF (0.59) | TNFNOD1MAPK1KCNA5PIP4K2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |