Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.69 |
| ▸ | FLT3 | P36888 | 10/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386386 | 0.89 | KDR (0.68) | KDRFLT3FGFR3 | |
| SCHEMBL3379605 | 0.86 | KDR (0.67) | KDRFLT3FGFR3PIK3CAMTOR | |
| SCHEMBL3385439 | 0.86 | FLT3 (0.53) | KDRFLT3 | |
| SCHEMBL3186080 | 0.85 | KDR (0.74) | KDRFLT3FGFR3PIK3CAMTOR | |
| SCHEMBL27686815 | 0.84 | KDR (0.64) | KDRFLT3FGFR3PIK3CAMTOR | |
| SCHEMBL3198806 | 0.84 | FLT3 (0.50) | KDRFLT3 | |
| SCHEMBL16965613 | 0.82 | KDR (0.74) | KDRFLT3FGFR3PIK3CAMTOR | |
| SCHEMBL5251631 | 0.82 | KDR (1.00) | KDRFLT3FGFR3 | |
| SCHEMBL5248501 | 0.82 | KDR (1.00) | KDRFLT3FGFR3 | |
| SCHEMBL3197100 | 0.82 | FLT3 (0.61) | KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |