Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.78 |
| ▸ | KIT | P10721 | 5/20 | 0.78 |
| ▸ | FLT3 | P36888 | 5/20 | 0.78 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.78 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.78 |
| ▸ | CSF1R | P07333 | 4/20 | 0.78 |
| ▸ | FLT1 | P17948 | 4/20 | 0.78 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.78 |
| ▸ | FLT4 | P35916 | 3/20 | 0.78 |
| ▸ | FYN | P06241 | 3/20 | 0.78 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.78 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.78 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.78 |
| ▸ | LCK | P06239 | 2/20 | 0.78 |
| ▸ | LYN | P07948 | 2/20 | 0.78 |
| ▸ | BLK | P51451 | 2/20 | 0.78 |
| ▸ | PLK4 | O00444 | 1/20 | 0.78 |
| ▸ | AURKA | O14965 | 1/20 | 0.78 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.78 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386584 | 0.91 | KDR (0.63) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL3387066 | 0.89 | KDR (0.74) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL422119 | 0.88 | KDR (1.00) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL3383253 | 0.87 | NTRK1 (0.59) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL3382781 | 0.86 | KDR (0.69) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL3382786 | 0.84 | NTRK1 (0.56) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL3384625 | 0.83 | KDR (0.58) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL3386591 | 0.80 | KDR (0.50) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL3384357 | 0.80 | KDR (0.60) | KDRKITFLT3NTRK1AURKB | |
| SCHEMBL1330237 | 0.80 | FGFR1 (0.70) | KDRKITFLT3NTRK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |