Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.54 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386109 | 0.89 | KDR (0.50) | KDRBRAFRAF1CA9TRPV1 | |
| SCHEMBL3384625 | 0.89 | KDR (0.58) | KDRBRAFRAF1CA9TRPV1 | |
| SCHEMBL3384548 | 0.88 | KDR (0.49) | KDRBRAFRAF1CA9LCK | |
| SCHEMBL3387247 | 0.85 | KDR (0.47) | KDRBRAFRAF1CA9LCK | |
| SCHEMBL3387701 | 0.83 | FGFR1 (0.51) | KDRBRAF | |
| SCHEMBL8739803 | 0.81 | KDR (0.49) | KDRBRAFAURKBLCKJAK3 | |
| SCHEMBL3387495 | 0.81 | RAF1 (0.53) | KDRBRAFRAF1MAPK14 | |
| SCHEMBL3386715 | 0.81 | KDR (0.58) | KDRBRAFRAF1CA9TRPV1 | |
| SCHEMBL3387510 | 0.80 | KDR (0.52) | KDRBRAFRAF1CA9AURKB | |
| SCHEMBL3387504 | 0.78 | KDR (0.57) | KDRBRAFRAF1TRPV1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |