Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.54 |
| ▸ | HCK | P08631 | 1/20 | 0.53 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | CSK | P41240 | 4/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.51 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.51 |
| ▸ | ABL2 | P42684 | 2/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384701 | 0.92 | BRAF (0.70) | BRAFMAPK14MAP3K7MAP4K2RAF1 | |
| SCHEMBL3388557 | 0.91 | MAPK14 (0.68) | MAPK14MAP3K7MAP4K2DDR1NR2C2 | |
| SCHEMBL3388410 | 0.90 | BRAF (0.71) | BRAFMAPK14MAP3K7MAP4K2RAF1 | |
| SCHEMBL3388452 | 0.88 | MAP3K7 (0.70) | BRAFMAPK14MAP3K7MAP4K2DDR1 | |
| SCHEMBL3387002 | 0.86 | LYN (0.55) | BRAFMAPK14MAP3K7MAP4K2DDR1 | |
| SCHEMBL3389218 | 0.85 | BRAF (0.64) | BRAFMAPK14MAP3K7MAP4K2DDR1 | |
| SCHEMBL3388908 | 0.84 | BRAF (0.53) | BRAFMAPK14MAP3K7MAP4K2DDR1 | |
| SCHEMBL3387394 | 0.83 | MAPK14 (0.58) | BRAFMAPK14MAP3K7MAP4K2DDR1 | |
| SCHEMBL3384646 | 0.81 | MAP3K7 (0.61) | BRAFMAPK14MAP3K7MAP4K2DDR1 | |
| SCHEMBL3387657 | 0.80 | MAP3K7 (0.51) | BRAFMAPK14MAP3K7MAP4K2HCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183248-B2 | Substituted pyrrolo[2,3-d]pyrimidines and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-05-22 | — | — | US | claimed |
| EP-1891066-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-12-22 | — | — | EP | claimed |
| US-20090118273-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2009-05-07 | — | — | US | claimed |
| EP-1891066-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-02-27 | — | — | EP | claimed |
| WO-2006124462-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2006-11-23 | — | — | WO | claimed |
| US-8183248-B2 | Substituted pyrrolo[2,3-d]pyrimidines and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-05-22 | — | — | US | disclosed |
| US-8183248-B2 | Substituted pyrrolo[2,3-d]pyrimidines and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-05-22 | — | — | US | disclosed |
| US-8183248-B2 | Substituted pyrrolo[2,3-d]pyrimidines and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-05-22 | — | — | US | disclosed |
| EP-1891066-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-12-22 | — | — | EP | disclosed |
| US-20090118273-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2009-05-07 | — | — | US | disclosed |
| US-20090118273-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2009-05-07 | — | — | US | disclosed |
| US-20090118273-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2009-05-07 | — | — | US | disclosed |
| EP-1891066-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006124462-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118273-A1 | Compounds and Compositions as Protein Kinase Inhibitors | SRC, FYN, SYK | BRAF 77/4885MAPK14 226/4885MAP3K7 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.