Sugi Predict

Sugi Predict / Compounds / SCHEMBL3387632

SCHEMBL3387632

SCHEMBL3387632

COC(=O)c1n[nH]c2ccc(-c3ccc(N)cc3)cc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKAA1 Q13131 2/20 0.60
▸ PRKAG1 P54619 1/20 0.60
▸ PRKAB1 Q9Y478 1/20 0.60
▸ KDM4E B2RXH2 1/20 0.58
▸ STAT3 P40763 1/20 0.58
▸ HIF1A Q16665 1/20 0.58
▸ CDC7 O00311 2/20 0.53
▸ DYRK1A Q13627 10/20 0.51
▸ GSK3B P49841 3/20 0.51
▸ DYRK3 O43781 2/20 0.51
▸ MAP4K4 O95819 2/20 0.51
▸ CDK1 P06493 2/20 0.51
▸ CDK2 P24941 2/20 0.51
▸ MARK3 P27448 2/20 0.51
▸ CLK2 P49760 2/20 0.51
▸ CSNK2A1 P68400 2/20 0.51
▸ CDK5 Q00535 2/20 0.51
▸ CAMK2B Q13554 2/20 0.51
▸ CAMK2G Q13555 2/20 0.51
▸ CAMK2D Q13557 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL173308 0.88 KDM4E (0.65) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL1141712 0.86 PRKAA1 (0.54) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL11911440 0.85 PRKAA1 (0.56) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
Hydrochloric Acid SCHEMBL1141705 0.85 PRKAA1 (0.53) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL14574212 0.81 KDM4E (0.63) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL4793050 0.80 KDM4E (0.65) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL3387378 0.79 PDPK1 (0.60) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL6607918 0.79 KDM4E (0.60) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL4794844 0.78 KDM4E (0.63) PRKAA1PRKAG1PRKAB1KDM4ESTAT3
SCHEMBL4291226 0.78 KDM4E (0.63) PRKAA1PRKAG1PRKAB1KDM4ESTAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8754209-B2 Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2014-06-17 — — US claimed
US-20120130069-A1 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2012-05-24 — — US claimed
CN-102239150-A Novel indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient KOREA INST SCI & TECH 2011-11-09 — — CN claimed
US-8754209-B2 Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2014-06-17 — — US disclosed
US-8754209-B2 Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2014-06-17 — — US disclosed
US-20120130069-A1 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2012-05-24 — — US disclosed
US-20120130069-A1 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2012-05-24 — — US disclosed
CN-102239150-A Novel indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient KOREA INST SCI & TECH 2011-11-09 — — CN disclosed
WO-2010064875-A2 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2010-06-10 — — WO disclosed
WO-2010064875-A2 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2010-06-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120130069-A1 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT RAF1, RET, KDR PRKAA1 285/4885PRKAG1 691/4885PRKAB1 587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.