Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558688 | 0.81 | SLC6A2 (0.45) | ALOX5 | |
| SCHEMBL17320338 | 0.76 | CYP3A4 (0.43) | LMNAHPGDEPHX2KMT2APOLB | |
| SCHEMBL4560519 | 0.75 | OPRL1 (0.41) | ALOX5 | |
| SCHEMBL4862036 | 0.74 | KMT2A (0.39) | EPHX1LMNAHPGDKMT2ARECQL | |
| SCHEMBL17499960 | 0.74 | CYP2D6 (0.39) | LMNAHPGDKMT2APOLB | |
| SCHEMBL17311743 | 0.74 | CYP2D6 (0.39) | LMNAHPGDKMT2APOLB | |
| SCHEMBL17311744 | 0.74 | CYP2D6 (0.39) | LMNAHPGDKMT2APOLB | |
| SCHEMBL4558510 | 0.72 | OPRL1 (0.39) | EPHX1LMNAHPGDKMT2A | |
| SCHEMBL4973221 | 0.72 | RECQL (0.38) | ALOX5EPHX1LMNAHPGDEPHX2 | |
| SCHEMBL17311691 | 0.70 | CYP3A4 (0.39) | LMNAEPHX2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010051373-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2010-05-06 | — | — | WO | disclosed |