Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10387186 | 0.77 | CYP1A2 (0.52) | HPGDALDH1A1TSHRMMP13KMT2A | |
| SCHEMBL7583313 | 0.76 | HPGD (0.55) | HPGDSMN1; SMN2ALDH1A1TSHRKMT2A | |
| SCHEMBL10389701 | 0.76 | HPGD (0.58) | HPGDSMN1; SMN2ALDH1A1TSHRMMP13 | |
| SCHEMBL14862482 | 0.76 | TSHR (0.49) | HPGDSMN1; SMN2ALDH1A1TP53TSHR | |
| SCHEMBL7574279 | 0.76 | HPGD (0.51) | HPGDSMN1; SMN2ALDH1A1TP53TSHR | |
| SCHEMBL1900364 | 0.76 | KMT2A (0.54) | HPGDSMN1; SMN2TP53TSHRMMP13 | |
| SCHEMBL3899987 | 0.75 | IDO1 (0.42) | HPGDALDH1A1TSHRKMT2A | |
| SCHEMBL3392211 | 0.73 | PLAU (0.47) | SMN1; SMN2ALDH1A1HDAC2HDAC3HDAC1 | |
| SCHEMBL14894197 | 0.73 | NR1H4 (0.85) | HPGDALDH1A1TP53NR1H4TSHR | |
| SCHEMBL11902028 | 0.72 | NR1H4 (0.79) | HPGDALDH1A1NR1H4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |