Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.53 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388885 | 0.94 | PTGDR2 (0.58) | PTGDR2LPAR1LPAR5PTGDRCYP3A4 | |
| SCHEMBL3386561 | 0.91 | PTGDR2 (0.60) | PTGDR2LPAR1LPAR5PTGDRCYP3A4 | |
| SCHEMBL20669557 | 0.89 | PTGDR2 (0.53) | PTGDR2LPAR1LPAR5PTGDRCYP3A4 | |
| SCHEMBL3389225 | 0.89 | PTGDR2 (0.42) | PTGDR2LPAR1PTGDRCYP3A4MEN1 | |
| SCHEMBL3391048 | 0.86 | PTGDR2 (0.69) | PTGDR2PTGDRCYP3A4MEN1KMT2A | |
| SCHEMBL3389809 | 0.86 | PTGDR2 (0.46) | PTGDR2PTGDRCYP3A4KDM4EALDH1A1 | |
| SCHEMBL3386400 | 0.85 | PTGDR2 (0.44) | PTGDR2LPAR1PTGDRCYP3A4MEN1 | |
| SCHEMBL3384276 | 0.82 | PTGDR2 (0.43) | PTGDR2PTGDRCYP3A4KDM4EALDH1A1 | |
| SCHEMBL3386649 | 0.81 | PTGDR2 (0.59) | PTGDR2PTGDRCYP3A4MEN1KMT2A | |
| SCHEMBL3422370 | 0.80 | PTGDR2 (0.44) | PTGDR2PTGDRCYP3A4TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378107-B2 | Heteroaryl antagonists of prostaglandin D2 receptors | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8378107-B2 | Heteroaryl antagonists of prostaglandin D2 receptors | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8378107-B2 | Heteroaryl antagonists of prostaglandin D2 receptors | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20110319445-A1 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319445-A1 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319445-A1 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| WO-2010039977-A2 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039977-A2 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319445-A1 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PTGDR, PTGDR2, PTGER2 | PTGDR2 2/4885LPAR1 86/4885LPAR5 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.