Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAC1 | P63000 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.48 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.44 |
| ▸ | CCR4 | P51679 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639296 | 0.89 | RAC1 (0.98) | RAC1MAPTKCNH3DOT1LCACNA2D1 | |
| Hydrochloric Acid SCHEMBL3511071 | 0.88 | RAC1 (1.00) | RAC1MAPTKCNH3DOT1LCACNA2D1 | |
| SCHEMBL3389537 | 0.81 | RAC1 (0.68) | RAC1MAPTKCNH3CACNA2D1CCR4 | |
| SCHEMBL13868216 | 0.79 | RAC1 (0.81) | RAC1MAPTKCNH3DOT1LCACNA2D1 | |
| SCHEMBL14825396 | 0.78 | RAC1 (0.80) | RAC1MAPTDOT1L | |
| SCHEMBL3392632 | 0.74 | RAC1 (0.58) | RAC1MAPTKCNH3CACNA2D1CCR4 | |
| Ammonia Solution, Strong SCHEMBL3727545 | 0.71 | RAC1 (0.69) | RAC1MAPTKCNH3CACNA2D1CCR4 | |
| SCHEMBL3388177 | 0.70 | RAC1 (0.51) | RAC1MAPTKCNH3CACNA2D1CCR4 | |
| SCHEMBL3392739 | 0.70 | CCR4 (0.54) | RAC1MAPTKCNH3CACNA2D1CCR4 | |
| SCHEMBL4452813 | 0.69 | HSP90AA1 (0.45) | RAC1MAPTCACNA2D1CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2258370-A1 | Treatment of malignant diseases | Medizinische Universität Wien (AT) | 2010-12-08 | — | — | EP | disclosed |
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | disclosed |