Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3174282 | 0.91 | CDK8 (0.52) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL378881 | 0.89 | CDK8 (0.63) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL3174427 | 0.88 | CDK8 (0.53) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL3181946 | 0.87 | CDK8 (0.52) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL3174490 | 0.85 | CDK8 (0.53) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL3777160 | 0.85 | MAPK14 (0.57) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL15485125 | 0.83 | CDK8 (0.62) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL2443743 | 0.83 | CDK8 (0.63) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL3165072 | 0.82 | CDK8 (0.45) | CDK8MAPK14CCNCMAPK13MAPK12 | |
| SCHEMBL3190583 | 0.82 | MAPK14 (0.58) | CDK8MAPK14CCNCMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |