Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 7/20 | 0.54 |
| ▸ | KCNJ5 | P48544 | 7/20 | 0.54 |
| ▸ | KCNJ3 | P48549 | 7/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392454 | 0.96 | MAPK14 (0.51) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3182713 | 0.89 | KCNJ6 (0.57) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3388891 | 0.87 | KCNJ6 (0.53) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3388946 | 0.86 | KCNJ6 (0.61) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3424342 | 0.85 | KCNJ6 (0.54) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3392591 | 0.84 | MAPK14 (0.50) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3390021 | 0.82 | MAPK14 (0.57) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3388947 | 0.81 | KCNJ6 (0.50) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3389372 | 0.81 | KCNJ6 (0.53) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 | |
| SCHEMBL3182742 | 0.81 | KCNJ6 (0.51) | KCNJ6KCNJ5KCNJ3MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |