Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 15/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390099 | 0.90 | CYP19A1 (0.53) | CYP19A1CYP3A4 | |
| SCHEMBL3388807 | 0.86 | CYP19A1 (0.42) | CYP19A1 | |
| SCHEMBL3395050 | 0.83 | CYP19A1 (0.48) | CYP19A1CYP3A4 | |
| SCHEMBL10693298 | 0.75 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL9219622 | 0.74 | HTR2C (0.54) | CYP3A4 | |
| SCHEMBL11366789 | 0.70 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP2D6CYP1A2FNTA | |
| SCHEMBL3394928 | 0.69 | CYP19A1 (0.50) | CYP19A1 | |
| SCHEMBL14116477 | 0.69 | CYP19A1 (0.63) | CYP19A1CYP3A4CYP2D6CYP1A2FNTA | |
| SCHEMBL8917184 | 0.69 | CYP19A1 (0.84) | CYP19A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL9582367 | 0.68 | HIF1A (0.45) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087478-A1 | HIF-1 Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-08 | — | — | US | claimed |
| US-20070099952-A1 | Hif-1 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | claimed |
| EP-1613311-A2 | HIF-1 INHIBITORS | Emory University (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2004087066-A2 | HIF-1 INHIBITORS | EMORY UNIVERSITY (US) | 2004-10-14 | — | — | WO | claimed |
| US-20100087478-A1 | HIF-1 Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-08 | — | — | US | disclosed |
| US-7652033-B2 | HIF-1 inhibitors | EMORY UNIVERSITY (US) | 2010-01-26 | — | — | US | disclosed |
| US-20070099952-A1 | Hif-1 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
| US-20070099952-A1 | Hif-1 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099952-A1 | Hif-1 inhibitors | HIF1AN, HIF1A, EGLN2 | CYP19A1 1742/4885CYP3A4 3468/4885CYP2D6 2337/4885 |
| US-20100087478-A1 | HIF-1 Inhibitors | HIF1AN, HIF1A, EGLN2 | CYP19A1 1742/4885CYP3A4 3468/4885CYP2D6 2337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.