Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.42 |
| ▸ | STK17B | O94768 | 3/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 3/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399078 | 0.82 | SYK (0.60) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL27801764 | 0.79 | SYK (0.57) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3399056 | 0.77 | SYK (0.54) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL27822514 | 0.76 | SYK (0.69) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396681 | 0.76 | SYK (0.57) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2345973 | 0.76 | SYK (0.55) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2279533 | 0.76 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2280768 | 0.75 | SYK (0.56) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396114 | 0.73 | JAK2 (0.37) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2344596 | 0.73 | SYK (0.56) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |