SCHEMBL3391798

SCHEMBL3391798

CSC(=O)N(C)C1CN(c2ccc(N3CCN(C(=O)CSc4cc(Cl)ccc4Cl)CC3)c(F)c2)C(=O)O1

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.45
F10 P00742 9/20 0.44
MAOA P21397 3/20 0.42
LMNA P02545 1/20 0.40
PTGS1 P23219 1/20 0.40
CALML3 P27482 1/20 0.40
SDHA P31040 1/20 0.40
FPR1 P21462 1/20 0.38
FPR2 P25090 1/20 0.38
MC4R P32245 1/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3390795 0.93 MAOB (0.45) MAOBF10MAOALMNAPTGS1
SCHEMBL3394838 0.85 MAOB (0.51) MAOBF10MAOALMNAPTGS1
SCHEMBL3391796 0.84 F10 (0.56) MAOBF10MAOALMNAPTGS1
SCHEMBL3391793 0.84 MAOB (0.52) MAOBF10MAOALMNAPTGS1
SCHEMBL3392749 0.83 MAOB (0.47) MAOBF10MAOALMNAPTGS1
SCHEMBL3397707 0.82 MAOB (0.49) MAOBF10MAOALMNAPTGS1
SCHEMBL3396428 0.81 MAOB (0.46) MAOBF10MAOALMNAPTGS1
SCHEMBL3390790 0.81 F10 (0.57) MAOBF10MAOALMNAPTGS1
SCHEMBL3390798 0.80 F10 (0.57) MAOBF10MAOALMNAPTGS1
SCHEMBL3395668 0.80 MAOB (0.50) MAOBF10MAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100234390-A1 NOVEL COMPOUND AND THEIR USE ORCHID RESEARCH LABORATORIES LIMITED (IN) 2010-09-16 US claimed
US-20100234390-A1 NOVEL COMPOUND AND THEIR USE ORCHID RESEARCH LABORATORIES LIMITED (IN) 2010-09-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100234390-A1 NOVEL COMPOUND AND THEIR USE HTRA1, PRSS1, PRNP MAOB 2054/4885F10 3863/4885MAOA 2174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.