Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.68 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.53 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14438225 | 0.92 | HSP90AB1 (0.69) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL13539605 | 0.85 | HSP90AB1 (0.63) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1394943 | 0.82 | HSP90AA1 (0.77) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3396045 | 0.81 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3394034 | 0.81 | HSP90AB1 (0.76) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14438219 | 0.80 | HSP90AB1 (0.62) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14568070 | 0.80 | HSP90AB1 (0.65) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14568074 | 0.79 | HSP90AB1 (0.84) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14438224 | 0.79 | HSP90AB1 (0.71) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL6029166 | 0.78 | HSP90AB1 (0.70) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014172616-A2 | METHODS, COMPOSITIONS AND KITS FOR PROMOTING MOTOR NEURON SURVIVAL AND TREATING AND DIAGNOSING NEURODEGENERATIVE DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-10-23 | — | — | WO | disclosed |
| WO-2010048273-A2 | METHODS AND COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-29 | — | — | WO | disclosed |