Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 7/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048569 | 0.82 | ZAP70 (0.63) | ZAP70LRRK2FERJAK1JAK2 | |
| SCHEMBL12928940 | 0.81 | ZAP70 (0.61) | ZAP70LRRK2FERJAK1JAK2 | |
| SCHEMBL27806121 | 0.80 | ZAP70 (0.59) | ZAP70LRRK2FERJAK1JAK2 | |
| SCHEMBL1048472 | 0.79 | ZAP70 (0.59) | ZAP70LRRK2FERJAK1JAK2 | |
| SCHEMBL1047208 | 0.78 | ZAP70 (0.63) | ZAP70LRRK2FERJAK1JAK2 | |
| SCHEMBL1047865 | 0.76 | ZAP70 (0.60) | ZAP70LRRK2FERJAK1JAK2 | |
| SCHEMBL3390291 | 0.74 | ZAP70 (0.62) | ZAP70TYK2SYK | |
| SCHEMBL1047738 | 0.73 | ZAP70 (1.00) | ZAP70JAK2SYK | |
| SCHEMBL1049180 | 0.73 | ZAP70 (0.66) | ZAP70FERJAK1JAK2 | |
| SCHEMBL1158341 | 0.69 | ZAP70 (0.49) | ZAP70FERJAK2TYK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |