Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 8/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391089 | 0.93 | MAPK14 (0.52) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL3392453 | 0.92 | MAPK14 (0.53) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL13528639 | 0.88 | MAPK14 (0.51) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL2951258 | 0.88 | MAPK14 (0.54) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL3394275 | 0.86 | MAPK14 (0.49) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL3388913 | 0.85 | MAPK14 (0.55) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL3390223 | 0.84 | MAPK14 (0.52) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL3178035 | 0.84 | MAPK14 (0.46) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL3423893 | 0.82 | MAPK14 (0.62) | MAPK13MAPK14MAPK12MAPK11PTK2 | |
| SCHEMBL3390254 | 0.82 | MAPK14 (0.49) | MAPK13MAPK14MAPK12MAPK11PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |