Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 5/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | MUSK | O15146 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388852 | 0.97 | MAPK14 (0.53) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3388913 | 0.90 | MAPK14 (0.55) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3392618 | 0.89 | MAPK14 (0.51) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL4641732 | 0.88 | MAPK14 (0.52) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3392453 | 0.87 | MAPK14 (0.53) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3390159 | 0.86 | MAPK14 (0.48) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3180524 | 0.86 | MAPK14 (0.50) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL13528641 | 0.85 | MAPK14 (0.52) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3180128 | 0.84 | MAPK14 (0.49) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3170571 | 0.84 | MAPK14 (0.60) | MAPK14MAPK12MAPK13MAPK11PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |