Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185464 | 0.95 | PAK1 (0.44) | NMT1PAK1PAK4ABL1SRC | |
| SCHEMBL12185447 | 0.95 | PAK1 (0.44) | NMT1PAK1PAK4ABL1SRC | |
| SCHEMBL12185305 | 0.91 | CLK1 (0.55) | NMT1PAK1PAK4CLK1CLK2 | |
| SCHEMBL12185366 | 0.91 | PAK1 (0.43) | NMT1PAK1PAK4ABL1SRC | |
| SCHEMBL12185784 | 0.91 | PAK1 (0.43) | NMT1PAK1PAK4ABL1SRC | |
| SCHEMBL12185449 | 0.90 | EGFR (0.54) | NMT1ABL1SRCHDAC1EGFR | |
| SCHEMBL12185320 | 0.89 | MAPT (0.44) | NMT1PAK1PAK4ABL1SRC | |
| SCHEMBL12185332 | 0.89 | MAPT (0.44) | NMT1PAK1PAK4ABL1SRC | |
| SCHEMBL12185474 | 0.89 | CCNT1 (0.46) | PAK1PAK4ABL1CLK1CLK2 | |
| SCHEMBL12185480 | 0.89 | EGFR (0.55) | PAK1PAK4ABL1SRCHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010119050-A1 | NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | WO | claimed |
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010119050-A1 | NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010119050-A1 | NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | WO | disclosed |
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | disclosed |