Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 5/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | ABL2 | P42684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284332 | 0.93 | BACE1 (0.39) | BACE1KCNH2CTSDBACE2PDE4A | |
| SCHEMBL2284328 | 0.93 | BACE1 (0.39) | BACE1KCNH2CTSDBACE2PDE4A | |
| SCHEMBL3391476 | 0.88 | BACE1 (0.37) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL13825376 | 0.83 | BACE1 (0.41) | BACE1KCNH2CTSDBACE2PDE4A | |
| SCHEMBL2285394 | 0.83 | BACE1 (0.41) | BACE1CTSD | |
| SCHEMBL2285384 | 0.83 | BACE1 (0.41) | BACE1CTSD | |
| SCHEMBL2277206 | 0.80 | BACE1 (0.40) | BACE1KCNH2CTSD | |
| SCHEMBL2277203 | 0.80 | BACE1 (0.40) | BACE1KCNH2CTSD | |
| SCHEMBL2283083 | 0.80 | BACE1 (0.38) | BACE1KCNH2CTSDPDE4APDE4D | |
| SCHEMBL2283087 | 0.80 | BACE1 (0.38) | BACE1KCNH2CTSDPDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |