Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.43 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3174170 | 0.87 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3180310 | 0.85 | KCNJ6 (0.64) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL6690236 | 0.76 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL2960108 | 0.75 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3391053 | 0.75 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3174332 | 0.74 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL6692103 | 0.74 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| Hydrochloric Acid SCHEMBL4605495 | 0.74 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL6692759 | 0.74 | NPC1 (0.61) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL3185809 | 0.73 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |