Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.56 |
| ▸ | CTSD | P07339 | 14/20 | 0.56 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.46 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2281222 | 0.94 | BACE1 (0.59) | BACE1CTSDBACE2REN | |
| SCHEMBL2281226 | 0.94 | BACE1 (0.59) | BACE1CTSDBACE2REN | |
| SCHEMBL2283794 | 0.93 | BACE1 (0.58) | BACE1CTSDBACE2REN | |
| SCHEMBL2283799 | 0.93 | BACE1 (0.58) | BACE1CTSDBACE2REN | |
| SCHEMBL3393627 | 0.89 | BACE1 (0.49) | BACE1CTSDBACE2REN | |
| Formic Acid SCHEMBL2283650 | 0.89 | BACE1 (0.54) | BACE1CTSDBACE2REN | |
| SCHEMBL2284071 | 0.85 | BACE1 (0.51) | BACE1CTSDBACE2REN | |
| SCHEMBL2284077 | 0.85 | BACE1 (0.51) | BACE1CTSDBACE2REN | |
| SCHEMBL2281803 | 0.85 | BACE1 (0.58) | BACE1CTSDBACE2 | |
| SCHEMBL2281795 | 0.85 | BACE1 (0.58) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | claimed |