Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 15/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396024 | 0.81 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3395967 | 0.78 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3397111 | 0.76 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1882600 | 0.67 | TDP1 (0.47) | — | |
| SCHEMBL5964706 | 0.67 | TDP1 (0.44) | — | |
| SCHEMBL11748681 | 0.67 | KDM4E (0.44) | — | |
| SCHEMBL215343 | 0.67 | TDP1 (0.46) | — | |
| SCHEMBL3394665 | 0.66 | HSP90AB1 (0.78) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL18138425 | 0.66 | TDP1 (0.45) | — | |
| SCHEMBL14494983 | 0.65 | POLB (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |