Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.47 |
| ▸ | NEK2 | P51955 | 12/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342741 | 0.95 | SYK (0.61) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2280507 | 0.83 | SYK (0.63) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3395340 | 0.82 | SYK (0.53) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL13689555 | 0.82 | SYK (0.61) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2279533 | 0.79 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275925 | 0.79 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277878 | 0.78 | SYK (0.76) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2279926 | 0.78 | SYK (0.76) | SYKCYP2C9JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL2278432 | 0.78 | SYK (0.57) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277145 | 0.77 | SYK (0.68) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |