Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393026 | 0.78 | MAPK1 (0.46) | MAPK1 | |
| SCHEMBL25302723 | 0.77 | MAPK1 (0.57) | MAPK1 | |
| SCHEMBL3395483 | 0.74 | MAPK1 (0.47) | MAPK1 | |
| SCHEMBL3393952 | 0.72 | MAPK1 (0.54) | MAPK1 | |
| SCHEMBL1352615 | 0.71 | MAPK1 (0.57) | MAPK1 | |
| SCHEMBL29936350 | 0.68 | MAPK1 (0.57) | MAPK1 | |
| SCHEMBL1352440 | 0.68 | MAPK1 (0.57) | MAPK1 | |
| SCHEMBL14376008 | 0.67 | MAPK1 (0.48) | MAPK1 | |
| SCHEMBL18209957 | 0.67 | MAPK1 (0.48) | MAPK1 | |
| SCHEMBL18534405 | 0.66 | MAPK1 (0.54) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |