Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23243835 | 1.00 | EPHX1 (0.53) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL29617381 | 1.00 | EPHX1 (0.53) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL20559002 | 1.00 | EPHX1 (0.53) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL30078348 | 0.94 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL21610579 | 0.94 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL23256074 | 0.94 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL293955 | 0.88 | EPHX1 (0.56) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL28808883 | 0.88 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL16194851 | 0.84 | EPHX1 (0.61) | EPHX1ALDH1A1HPGDCYP19A1LMNA | |
| SCHEMBL6387314 | 0.84 | EPHX1 (0.61) | EPHX1ALDH1A1HPGDCYP19A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105682-A1 | CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105682-A1 | CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1B, CACNA1F | EPHX1 1932/4885ALDH1A1 2138/4885HPGD 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.