Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.80 |
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.80 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396045 | 0.89 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1ADORA2AHSP90B1TRAP1 | |
| SCHEMBL3389641 | 0.89 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1ADORA2A | |
| SCHEMBL3395258 | 0.88 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1ADORA2AHSP90B1TRAP1 | |
| SCHEMBL3396299 | 0.87 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3393834 | 0.83 | HSP90AB1 (0.74) | HSP90AB1HSP90AA1 | |
| SCHEMBL3395792 | 0.81 | HSP90AB1 (0.88) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3395139 | 0.81 | HSP90AB1 (0.88) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3396118 | 0.81 | HSP90AB1 (0.86) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14568074 | 0.80 | HSP90AB1 (0.84) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3397577 | 0.80 | HSP90AB1 (0.85) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |
| EP-1670802-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | Conforma Therapeutic Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028434-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |