Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.62 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.62 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.62 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.62 |
| ▸ | ADK | P55263 | 1/20 | 0.62 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.62 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394869 | 0.94 | EGFR (0.75) | EGFRERBB2EPHA2EPHB4GAK | |
| SCHEMBL3391916 | 0.92 | EGFR (0.77) | EGFRERBB2EPHA2EPHB4GAK | |
| SCHEMBL3391493 | 0.89 | EGFR (0.72) | EGFRERBB2EPHA2EPHB4RIPK2 | |
| SCHEMBL3394547 | 0.85 | EGFR (0.71) | EGFRERBB2EPHA2EPHB4KDR | |
| SCHEMBL3390840 | 0.85 | EGFR (0.72) | EGFRERBB2EPHA2EPHB4RIPK2 | |
| SCHEMBL3433231 | 0.85 | EGFR (0.65) | EGFRERBB2EPHA2EPHB4GAK | |
| SCHEMBL3390792 | 0.83 | EGFR (0.64) | EGFRERBB2EPHA2EPHB4GAK | |
| SCHEMBL3395571 | 0.83 | EGFR (1.00) | EGFRERBB2EPHB4RIPK2RET | |
| SCHEMBL3391766 | 0.83 | EGFR (0.73) | EGFRERBB2EPHB4RIPK2RET | |
| SCHEMBL3127175 | 0.83 | EGFR (0.92) | EGFRERBB2EPHA2EPHB4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167492-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | Hanmi Pharm. Co., Ltd. (KR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008150118-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | HANMI PHARM. CO., LTD. (KR) | 2008-12-11 | — | — | WO | disclosed |