Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 3/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399404 | 0.91 | MAP4K1 (0.45) | MAP4K1ALKCDK2SYKDGAT1 | |
| SCHEMBL3394239 | 0.91 | FLT3 (0.40) | MAP4K1FLT3ALKCDK1CCNB1 | |
| SCHEMBL3398822 | 0.87 | ITGB2 (0.39) | FLT3ALKCDK1CCNB1CCNE1 | |
| SCHEMBL3395584 | 0.87 | MAP4K1 (0.45) | MAP4K1SYKMAPK1 | |
| SCHEMBL3396434 | 0.86 | MAP4K1 (0.43) | MAP4K1CDK2SYKKDRMAPT | |
| SCHEMBL3400750 | 0.84 | JAK3 (0.46) | JAK3 | |
| SCHEMBL3399624 | 0.82 | JAK3 (0.37) | MAP4K1ALKSYKKDRMAPK1 | |
| SCHEMBL2281238 | 0.81 | JAK3 (0.52) | MAP4K1FLT3ALKCDK1CCNB1 | |
| SCHEMBL14655540 | 0.79 | MAP4K1 (0.48) | MAP4K1FLT3ALKCDK1CCNB1 | |
| SCHEMBL3398393 | 0.78 | JAK3 (0.36) | MAP4K1FLT3CDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |