Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.52 |
| ▸ | PDE8B | O95263 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.46 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392762 | 0.89 | PDE8B (0.63) | ADORA3ADORA2AADORA2BADORA1PDE8B | |
| SCHEMBL3396109 | 0.85 | HSP90AA1 (0.65) | ADORA3ADORA2AADORA2BADORA1PDE8B | |
| SCHEMBL3391863 | 0.82 | HSP90AB1 (0.45) | ADORA3ADORA2AADORA2BADORA1PDE8B | |
| SCHEMBL3395517 | 0.82 | HSP90AB1 (0.50) | ADORA3ADORA2AADORA2BADORA1PDE8B | |
| SCHEMBL3393789 | 0.81 | HSP90AB1 (0.50) | ADORA3ADORA2AADORA2BADORA1PDE8B | |
| SCHEMBL3394682 | 0.81 | HSP90AA1 (0.50) | ADORA3ADORA2AADORA2BADORA1PDE8B | |
| SCHEMBL3392701 | 0.80 | HSP90AB1 (0.67) | ADORA3ADORA2AADORA2BADORA1PDE8B | |
| SCHEMBL3393873 | 0.79 | ADORA2A (0.62) | ADORA3ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL3395507 | 0.78 | HSP90AB1 (0.74) | ADORA2AHSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL4046670 | 0.77 | ADORA2A (0.85) | ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |
| US-20070111997-A1 | Triazolopyrimidines and related analogs as HSP90-inhibitors | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-05-17 | — | — | US | disclosed |
| US-7129244-B2 | Triazolopyrimidines and related analogs as HSP90-inhibitors | CONFORMA THERAPEUTICS CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1670802-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | Conforma Therapeutic Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050113339-A1 | Triazolopyrimidines and related analogs as HSP90-inhibitors | CONFORMA THERAPEUTICS CORPORATION | 2005-05-26 | — | — | US | disclosed |
| WO-2005028434-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113339-A1 | Triazolopyrimidines and related analogs as HSP90-inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | ADORA3 4757/4885ADORA2A 4615/4885ADORA2B 4709/4885 |
| US-20070111997-A1 | Triazolopyrimidines and related analogs as HSP90-inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | ADORA3 4757/4885ADORA2A 4615/4885ADORA2B 4709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.