Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.42 |
| ▸ | CTSD | P07339 | 5/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282409 | 0.90 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2282412 | 0.90 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2284137 | 0.83 | BACE1 (0.42) | BACE1CTSDMEN1ALDH1A1LMNA | |
| SCHEMBL2284570 | 0.80 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL2284565 | 0.80 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL2276631 | 0.79 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2280431 | 0.79 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2276625 | 0.79 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2284610 | 0.78 | BACE1 (0.55) | BACE1CTSD | |
| SCHEMBL2284615 | 0.78 | BACE1 (0.55) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |