Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | TEC | P42680 | 1/20 | 0.56 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433231 | 0.92 | EGFR (0.65) | EGFRERBB2KDRFGFR1FLT1 | |
| SCHEMBL3390792 | 0.89 | EGFR (0.64) | EGFRERBB2KDREPHB4RIPK2 | |
| SCHEMBL3431651 | 0.89 | EGFR (0.64) | EGFRERBB2KDRFGFR1FLT1 | |
| SCHEMBL3391866 | 0.88 | EGFR (0.61) | EGFRERBB2KDRFLT1EPHB4 | |
| SCHEMBL3391916 | 0.88 | EGFR (0.77) | EGFRERBB2KDRFLT1EPHB4 | |
| SCHEMBL3391766 | 0.88 | EGFR (0.73) | EGFRERBB2EPHB4RIPK2RET | |
| Hydrochloric Acid SCHEMBL14843125 | 0.87 | EGFR (0.72) | EGFRERBB2EPHB4RIPK2RET | |
| SCHEMBL3393606 | 0.87 | EGFR (0.64) | EGFRERBB2KDRFGFR1FLT1 | |
| SCHEMBL3392498 | 0.87 | EGFR (0.64) | EGFRERBB2KDRFLT1EPHB4 | |
| SCHEMBL3391929 | 0.86 | EGFR (0.73) | EGFRERBB2KDRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167492-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | Hanmi Pharm. Co., Ltd. (KR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008150118-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | HANMI PHARM. CO., LTD. (KR) | 2008-12-11 | — | — | WO | disclosed |