Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.40 |
| ▸ | CTSD | P07339 | 8/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283897 | 0.89 | BACE1 (0.44) | BACE1CTSDAPPTAAR1BACE2 | |
| SCHEMBL2288132 | 0.89 | BACE1 (0.44) | BACE1CTSDAPPTAAR1BACE2 | |
| SCHEMBL2276631 | 0.82 | BACE1 (0.48) | BACE1CTSDAPPBACE2 | |
| SCHEMBL2280431 | 0.82 | BACE1 (0.48) | BACE1CTSDAPPBACE2 | |
| SCHEMBL2276625 | 0.82 | BACE1 (0.48) | BACE1CTSDAPPBACE2 | |
| SCHEMBL2281251 | 0.78 | BACE1 (0.53) | BACE1CTSDTAAR1 | |
| SCHEMBL2281248 | 0.78 | BACE1 (0.53) | BACE1CTSDTAAR1 | |
| SCHEMBL2282137 | 0.78 | BACE1 (0.51) | BACE1CTSDTAAR1BACE2 | |
| SCHEMBL2282142 | 0.78 | BACE1 (0.51) | BACE1CTSDTAAR1BACE2 | |
| SCHEMBL2284305 | 0.77 | BACE1 (0.44) | BACE1CTSDTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |