Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.77 |
| ▸ | KIT | P10721 | 15/20 | 0.77 |
| ▸ | FLT3 | P36888 | 14/20 | 0.77 |
| ▸ | VHL | P40337 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 5/20 | 0.60 |
| ▸ | CSF1R | P07333 | 5/20 | 0.60 |
| ▸ | FLT1 | P17948 | 5/20 | 0.60 |
| ▸ | FLT4 | P35916 | 5/20 | 0.60 |
| ▸ | LYN | P07948 | 4/20 | 0.60 |
| ▸ | SRC | P12931 | 4/20 | 0.60 |
| ▸ | BLK | P51451 | 4/20 | 0.60 |
| ▸ | FYN | P06241 | 3/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | INSR | P06213 | 2/20 | 0.59 |
| ▸ | MET | P08581 | 2/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421753 | 0.87 | KDR (1.00) | KDRKITFLT3VHLLCK | |
| SCHEMBL6073436 | 0.80 | KDR (0.79) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL420530 | 0.76 | KDR (0.73) | KDRKITFLT3VHLLCK | |
| SCHEMBL1703314 | 0.76 | KDR (1.00) | KDRKITFLT3VHLLCK | |
| SCHEMBL1703478 | 0.76 | KDR (1.00) | KDRKITFLT3VHLLCK | |
| SCHEMBL420902 | 0.76 | KDR (0.80) | KDRKITFLT3VHLLCK | |
| SCHEMBL423364 | 0.76 | KDR (0.76) | KDRKITFLT3VHLLCK | |
| SCHEMBL1660311 | 0.75 | KDR (0.78) | KDRKITFLT3VHLLCK | |
| SCHEMBL420430 | 0.75 | KDR (0.81) | KDRKITFLT3VHLLCK | |
| SCHEMBL13523211 | 0.75 | KDR (0.80) | KDRKITFLT3VHLLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-B1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LAB (US) | 2010-06-02 | — | — | EP | claimed |